SHORT REPORT Y chromosome evidence for a founder effect in Ashkenazi Jews
نویسندگان
چکیده
MRC/NHLS/Wits Human Genomic Diversity and Disease Research Unit, Division of Human Genetics, School of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa; Department of Hematology, Hebrew University – Hadassah Medical School and Hadassah University Hospital, Jerusalem, Israel; Laboratory of Biological Anthropology and Ancient DNA, Hebrew University – Hadassah School of Dental Medicine, Jerusalem, Israel
منابع مشابه
A population-genetic test of founder effects and implications for Ashkenazi Jewish diseases.
A founder effect can account for the presence of an allele at an unusually high frequency in an isolated population if the allele is selectively neutral and if all copies are identical by descent with a copy that either was carried by a founder individual or arose by mutation later. Here, a statistical test of both aspects of the founder-effect hypothesis is developed. The test is performed by ...
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A gene for autosomal recessive familial hyperinsulinism (HI) (OMIM: 256450), a neonatal metabolic disease characterized by inappropriate insulin secretion in the presence of severe hypoglycemia, was recently mapped to a 6.6 cM interval between the markers D11S926 and D11S928 on chromosome 11p in 15 families (1). In the current study we evaluated six additional families and five new markers, and...
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